I

FOUNDATIONS

1

Evolution, Science, and Molecular Biology

1

2

DNA: The Repository of Biological Information

23

3

Chemical Basis of Information Molecules

61

4

Protein Structure

93

5

Protein Function

133

II

NUCLEIC ACID STRUCTURE AND METHODS

6

DNA and RNA Structure

173

7

Studying Genes

211

8

Genomes, Transcriptomes, and Proteomes

259

9

Topology: Functional Deformations of DNA

297

10

Nucleosomes, Chromatin, and Chromosome Structure

331

III

INFORMATION TRANSFER

11

DNA Replication

363

12

DNA Mutation and Repair

413

13

Recombinational DNA Repair and Homologous Recombination

449

14

Site-Specific Recombination and Transposition

485

15

Transcription: DNA-Dependent Synthesis of RNA

519

16

RNA Processing

553

17

The Genetic Code

589

18

Protein Synthesis

617

IV

REGULATION

19

Regulating the Flow of Information

665

20

The Regulation of Gene Expression in Bacteria

693

21

The Transcriptional Regulation of Gene Expression in Eukaryotes

727

22

The Posttranscriptional Regulation of Gene Expression in Eukaryotes

759

Model Organisms Appendix

A-1

Glossary

G-1

Solutions to Problems

S-1

Index

I-1