FIGURE 2.3 Communication Within the Neuron: The Action Potential These drawings depict the ion channels in the membrane of a neuron’s axon. When sufficiently stimulated, the neuron depolarizes and an action potential begins. At each progressive segment of the axon’s membrane, sodium ion channels open and sodium ions rush into the interior of the axon. A split second later, the sodium ion channels close and potassium channels open, allowing potassium ions to flow out of the axon. As this sequence occurs, there is a change in the relative balance of positive and negative ions separated by the axon membrane. The electrical charge on the interior of the axon briefly changes from negative to positive. Once started, an action potential is self-sustaining and continues to the end of the axon. Following the action potential, the neuron repolarizes and reestablishes its negative electrical charge.