| 1337–1453 | Hundred Years' War |
| 1346–1353 | Black Death in Europe |
| 1358 | Jacquerie uprising in France |
| 1378–1417 | Great Schism divides papacy |
| 1378 | Ciompi Revolt in Florence |
| 1381 | Wat Tyler's Rebellion in England |
| 1386 | Union of Lithuania and Poland |
| 1414–1418 | Council of Constance ends Great Schism; Jan Hus burned at the stake |
| 1453 | Conquest of Constantinople by Ottoman Turks; end of Hundred Years' War |
| 1454 | Peace of Lodi |
| 1477 | Dismantling of duchy of Burgundy |
| 1478 | Inquisition begins in Spain |
| 1492 | Spain conquers Muslim stronghold of Granada; expels Jews |