Yeast

High-temperature growth

RHO2

GTPase

Arabidopsis

Flowering time

CRY2

Cryptochrome

Maize

Branching

Tb1

Transcription factor

Maize

Flowering time

Vgt

Transcription factor

Rice

Photoperiod sensitivity

Hd1

Transcription factor

Rice

Photoperiod sensitivity

CK2a

Casein kinase a subunit

Tomato

Fruit-sugar content

Brix9-2-5

Invertase

Tomato

Fruit weight

Fw2.2

Cell-cell signaling

Drosophila

Bristle number

Scabrous

Secreted glycoprotein

Cattle

Milk yield

DGAT1

Diacylglycerol acyltransferase

Mice

Colon cancer

Moml

Modifier of a tumor-suppressor gene

Mice

Type 1 diabetes

I-Aβ

Histocompatibility antigen

Humans

Asthma

ADAM33

Metalloproteinase-domain-containing protein

Humans

Alzheimer’s disease

ApoE

Apolipoprotein

Humans

Type 1 diabetes

HLA-DQA

MHC class II surface glycoprotein

Source: A. M. Glazier et al., Science 298, 2002, 2345–2349.