Book Title
About the Authors
Introduction
Contents in Brief
Contents
Preface
Acknowledgments
Chapter Introduction
1.1 The Birth of Genetics
1.2 After Cracking the Code
1.3 Genetics Today
SUMMARY
KEY TERMS
PROBLEMS
Chapter Introduction
2.1 Single-Gene Inheritance Patterns
2.2 The Chromosomal Basis of Single-Gene Inheritance Patterns
2.3 The Molecular Basis of Mendelian Inheritance Patterns
2.4 Some Genes Discovered by Observing Segregation Ratios
2.5 Sex-Linked Single-Gene Inheritance Patterns
2.6 Human Pedigree Analysis
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
APPENDIX 2-1 Stages of Mitosis
APPENDIX 2-2 Stages of Meiosis
Chapter Introduction
3.1 Mendel's Law of Independent Assortment
3.2 Working with Independent Assortment
3.3 The Chromosomal Basis of Independent Assortment
3.4 Polygenic Inheritance
3.5 Organelle Genes: Inheritance Independent of the Nucleus
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
4.1 Diagnostics of Linkage
4.2 Mapping by Recombinant Frequency
4.3 Mapping with Molecular Markers
4.4 Centromere Mapping with Linear Tetrads
4.5 Using the Chi-square Test to Infer Linkage
4.6 Accounting for Unseen Multiple Crossovers
4.7 Using Recombination-Based Maps in Conjunction with Physical Maps
4.8 The Molecular Mechanism of Crossing Over
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
5.1 Working with Microorganisms
5.2 Bacterial conjugation
5.3 Bacterial Transformation
5.4 Bacteriophage Genetics
5.5 Transduction
5.6 Physical Maps and Linkage Maps compared
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
6.1 Interactions Between the Alleles of a single gene: Variations on Dominance
6.2 Interaction of Genes in Pathways
6.3 Inferring Gene Interactions
6.4 Penetrance and Expressivity
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
7.1 DNA: The Genetic Material
7.2 DNA Structure
7.3 Semiconservative Replication
7.4 Overview of DNA Replication
7.5 The Replisome: A Remarkable Replication Machine
7.6 Replication in Eukaryotic Organisms
7.7 Telomeres and Telomerase: Replication Termination
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
8.1 RNA
8.2 Transcription
8.3 Transcription in Eukaryotes
8.4 Intron Removal and Exon Splicing
8.5 Small Functional RNAs That Regulate and Protect the Eukaryotic Genome
SUMMARY
KEY TERMS
PROBLEMS
Chapter Introduction
9.1 Protein Structure
9.2 The Genetic Code
9.3 tRNA: The Adapter
9.4 Ribosomes
9.5 The Proteome
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
10.1 Overview: Isolating and Amplifying Specific DNA Fragments
10.2 Generating Recombinant DNA Molecules
10.3 Using Molecular Probes to Find and Analyze a Specific Clone of Interest
10.4 Determining the Base Sequence of a DNA Segment
10.5 Aligning Genetic and Physical Maps to Isolate Specific Genes
10.6 Genetic Engineering
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
11.1 Gene Regulation
11.2 Discovery of the lac System: Negative Control
11.3 Catabolite Repression of the lac Operon: Positive Control
11.4 Dual Positive and Negative Control: The Arabinose Operon
11.5 Metabolic Pathways and Additional Levels of Regulation: Attenuation
11.6 Bacteriophage Life Cycles: More Regulators, Complex Operons
11.7 Alternative Sigma Factors Regulate Large Sets of Genes
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
12.1 Transcriptional Regulation in Eukaryotes: An Overview
12.2 Lessons from Yeast: The GAL System
12.3 Dynamic Chromatin
12.4 Activation of Genes in a Chromatin Environment
12.5 Long-Term Inactivation of Genes in a Chromatin Environment
12.6 Gender-Specific Silencing of Genes and Whole Chromosomes
12.7 Post-Transcriptional Gene Repression by miRNAs
SUMMARY
KEY TERMS
SOLVED PROBLEMS
Chapter Introduction
13.1 The Genetic Approach to Development
13.2 The Genetic Toolkit for Drosophila Development
13.3 Defining the Entire Toolkit
13.4 Spatial Regulation of Gene Expression in Development
13.5 Post-transcriptional Regulation of Gene Expression in Development
13.6 From Flies to Fingers, Feathers, and Floor Plates: The Many Roles of Individual Toolkit Genes
13.7 Development and Disease
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
14.1 The Genomics Revolution
14.2 Obtaining the Sequence of a Genome
14.3 Bioinformatics: Meaning from Genomic Sequence
14.4 The Structure of the Human Genome
14.5 The Comparative Genomics of Humans with Other Species
14.6 Comparative Genomics and Human Medicine
14.7 Functional Genomics and Reverse Genetics
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
15.1 Discovery of Transposable Elements in Maize
15.2 Transposable Elements in Prokaryotes
15.3 Transposable Elements in Eukaryotes
15.4 The Dynamic Genome: More Transposable Elements Than Ever Imagined
15.5 Regulation of Transposable Element Movement by the Host
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
16.1 The Phenotypic Consequences of DNA Mutations
16.2 The Molecular Basis of Spontaneous Mutations
16.3 The Molecular Basis of Induced Mutations
16.4 Biological Repair Mechanisms
16.5 Cancer: An Important Phenotypic Consequence of Mutation
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
17.1 Changes in Chromosome Number
17.2 Changes in Chromosome Structure
17.3 Overall Incidence of Human Chromosome Mutations
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
18.1 Detecting Genetic Variation
18.2 The Gene-Pool Concept and the Hardy-Weinberg Law
18.3 Mating Systems
18.4 Genetic Variation and Its Measurement
18.5 The Modulation of Genetic Variation
18.6 Biological and Social Applications
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
19.1 Measuring Quantitative Variation
19.2 A Simple Genetic Model for Quantitative Traits
19.3 Broad-Sense Heritability: Nature Versus Nurture
19.4 Narrow-Sense Heritability: Predicting Phenotypes
19.5 Mapping QTL in Populations with Known Pedigrees
19.6 Association Mapping in Random-Mating Populations
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
Chapter Introduction
20.1 Evolution by Natural Selection
20.2 Natural Selection in Action: An Exemplary Case
20.3 Molecular Evolution: The Neutral Theory
20.4 Cumulative Selection and Multistep Paths to Functional Change
20.5 Morphological Evolution
20.6 The Origin of New Genes and Protein Functions
SUMMARY
KEY TERMS
SOLVED PROBLEMS
PROBLEMS
A Brief Guide to Model Organisms
Escherichia coli
Saccharomyces cerevisiae
Neurospora crassa
Arabidopsis thaliana
Caenorhabditis elegans
Drosophila melanogaster
Mus musculus
Appendix A Genetic Nomenclature
Appendix B Bioinformatic Resources for Genetics and Genomics
Index to Model Organisms
A Map of Genetics
Chapter Introduction
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
Chapter 10
Chapter 11
Chapter 12
Chapter 13
Chapter 14
Chapter 15
Chapter 16
Chapter 17
Chapter 18
Chapter 19
Chapter 20