Overview: What is the structure of a primary research article?
Title and Authors
Three Strategies for Understanding a Primary Research Article
The First Strategy: The Scan
The Scan of the Fan et al. Article
The Second Strategy: A Thorough Read
The Thorough Read of Fan et al.: The Introduction
Materials and Methods/Experimental Procedures
The Thorough Read of Fan et al.: The Results (focus on Figure 4A)
The Thorough Read of Fan et al.: The Discussion
The Third Strategy: Integration and Analysis
The Integration and Analysis of Fan et al.
Searching for an Article in Databases
Genetically Engineered Mice and Cancer Research
What Limitations Should We Consider?
Basis of the Global Association Study
WTCCC Findings and Follow-up Studies
The Next Step Following a GWAS
How GWASs Can Translate into Personalized Medicine
Making a miRNA Is Not Simple
In the Beginning There Were Only Two
A Novel RNA Field Is Born
The Role of the let-7 Family during Development
The Link between let-7 and Cancer
The Promise of let-7 as a Therapeutic for Cancer
The Model Organism Zebrafish
Naturally Occurring Mutations in Zebrafish
Forward Genetics Approaches in Zebrafish
Reverse Genetics Approaches in Zebrafish
Generating Zebrafish Mutants Using High-Throughput Genome-wide Approaches
Zebrafish as a Model System: An Ever-Expanding Field
The Polyglutamine Diseases
How do Polyglutamine Disease Proteins Cause Cell Damage?
Transcriptional Dysregulation
Mitochondrial Dysfunction
Impairment of the Ubiquitin-Proteasome System
SUMMARY: Unanswered Questions and Routes to Therapy