Life on Earth was entirely prokaryotic for about 2 billion years—
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Biologists theorize that the endomembrane system and the cell nucleus originated as the result of infoldings of the cell membrane.
The theory of endosymbiosis proposes that organelles arose when cells engulfed other cells, and this arrangement led to symbiotic relationships.
What is the origin of compartmentalization? We will describe the evolution of eukaryotic organelles in more detail in Key Concept 25.2. Here we outline two major themes in this process.