Polysome formation increases the rate of protein synthesis

Several ribosomes can work simultaneously at translating a single mRNA molecule, producing multiple polypeptides at the same time. As soon as the first ribosome has moved far enough from the site of translation initiation, a second initiation complex can form, then a third, and so on. An assemblage consisting of a strand of mRNA with its beadlike ribosomes and their growing polypeptide chains is called a polyribosome, or polysome (Figure 14.16). Cells that are actively synthesizing proteins contain large numbers of polysomes and few free ribosomes or ribosomal subunits.

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Figure 14.16 A Polysome (A) A polysome consists of multiple ribosomes and their growing polypeptide chains moving along an mRNA molecule. (B) An electron micrograph of a polysome.