key concept 25.4 Viruses Have Evolved Many Times

Some biologists do not think of viruses as living organisms, primarily because they are not cellular and must depend on cellular organisms for basic life functions such as replication and metabolism. But viruses are derived from the cells of living organisms. They use the same essential forms of genetic information storage and transmission as do cellular organisms. Viruses infect all cellular forms of life—both prokaryotes and eukaryotes. They replicate, mutate, evolve, and interact with other organisms, often causing serious diseases in their hosts. Finally, viruses clearly evolve independently of other organisms, so it is almost impossible not to treat them as a part of life.

focus your learning

  • Several factors limit phylogenetic analysis of viruses.

  • Some DNA viruses may have evolved from reduced cellular organisms.

  • Viruses can be used to fight bacterial infections.

Viruses are abundant in many environments. In some freshwater and marine ecosystems, they can occur at densities of up to 10 million viruses per milliliter of water. Biologists estimate that there are approximately 1031 individual virus particles on Earth—about 1,000 times the number of cellular organisms on the planet. Viruses have an enormous effect on the ecology of the oceans. Every day, about one-half of the bacteria in the oceans are killed by viruses. Huge marine blooms of bacteria, such as the Vibrio bloom that produced the milky seas described at the opening of this chapter, do not last for long because viral blooms soon follow the initial bacterial bloom. As the viruses increase, they begin to kill bacteria faster than the bacteria can reproduce.

Although viruses are everywhere and play an important role in many ecosystems, many aspects of their ecology and evolution are still poorly known. For example, several factors make virus phylogeny difficult to resolve. The tiny size of many virus genomes restricts the phylogenetic analyses that can be conducted to relate viruses to cellular organisms. Their rapid mutation rate, which results in rapid evolution of virus genomes, tends to cloud evolutionary relationships over long periods. There are no known fossil viruses (viruses are too small and delicate to fossilize), so the paleontological record offers no clues to virus origins. Finally, viruses are highly diverse (Figure 25.22). Several lines of evidence support the hypothesis that viruses have evolved repeatedly within each of the major groups of life. The difficulty in resolving deep evolutionary relationships of viruses makes a phylogeny-based classification difficult. Instead, viruses are placed in one of several functionally similar groups on the basis of the structure of their genomes (for example, whether the genomes are composed of RNA or DNA, and are double- or single-stranded). Most of these defined groups are not thought to represent monophyletic taxa, however.

image
Figure 25.22 Viruses Are Diverse Relatively small genomes and rapid evolutionary rates make it difficult to reconstruct phylogenetic relationships among viruses. Instead, viruses are classified largely by general characteristics of their genomes. The images here are computer artists’ reconstructions based on cryoelectron micrographs.