Sensation depends on which neurons receive action potentials from sensory cells

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All sensory systems process information in the form of action potentials. But the sensations we perceive—heat, pressure, light, smell, sound—differ because the messages from different kinds of sensory cells arrive at different places in the CNS. Action potentials arriving in the visual cortex of the brain are interpreted as light, whereas those that arrive in the olfactory bulb are perceived as smells.

A small patch of skin on your arm contains some sensory receptor cells that increase their firing rates when the skin is warmed and others that increase their activity when the skin is cooled. Other sensory cells in the same patch of skin respond to touch, irritants such as insect bites, and painful stimuli. These receptor cells transmit their messages through axons that enter the CNS at the spinal cord. The synapses made by those axons in the spinal cord and the subsequent pathways of transmission determine whether the stimulation of the skin on your arm is perceived as warmth, cold, touch, itch, or pain; even though the action potentials carried by all of these sensory axons are the same, the connectivity of each axon is specific for a given sensory modality. The intensity of a given sensation is coded by the frequency of the action potentials.

Some sensory receptors transmit information about the body’s internal conditions of which we are not consciously aware. The brain continuously receives information about body temperature, the concentrations of carbon dioxide and oxygen in the blood, arterial pressure, muscle tension, and the position of the limbs. All of this information is important for homeostasis but does not necessarily result in conscious sensation.

Some sensory receptor cells are assembled with other types of cells into sensory organs, such as eyes, ears, and noses, that enhance the ability of sensory cells to collect, filter, and amplify stimuli. Sensory systems include the sensory cells, their associated organs, and the neural networks that process the information.