Key Terms

activation loop 730

adapter protein 741

constitutive 723

cytokines 727

diabetes mellitus 769

erythropoietin (Epo) 727

Hedgehog (Hh) 755

HER family 735

insig-1(2)/SCAP/SREBP pathway 766

insulin 766

JAK/STAT pathway 727

kinase cascade 739

MAP kinase 739

matrix metalloprotease (MMP) family 761

NF-κB pathway 752

Notch/Delta pathway 761

nuclear-localization signal (NLS) 724

phosphoinositides 748

PI-3 kinase pathway 749

PPARγ 770

presenilin 1 762

primary cilium 757

protein kinase B (PKB) 750

PTEN phosphatase 751

Ras protein 739

receptor tyrosine kinases (RTKs) 726

regulated intramembrane proteolysis 764

scaffold proteins 748

SH2 domains 730

Smads 722

SRE-binding proteins (SREBPs) 764

transforming growth factor β (TGF-β) 722

Wnt 751