Receptor Serine Kinases That Activate Smads

Deheuninck, J., and K. Luo. 2009. Ski and SnoN, potent negative regulators of TGF-β signalling. Cell Res. 19:47–57.

Massagué, J. 2012. TGFβ signalling in context. Nat. Rev. Mol. Cell Biol. 13:617–630.

Xu, P., J. Liu, and R. Derynck. 2012. Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett. 586:1871–1884.

Cytokine Receptors and the JAK/STAT Signaling Pathway

Hattangadi, S., et al. 2011. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs and chromatin modifications. Blood 118:6258–6268.

Pfeifer, A. C., J. Timmer, and U. Klingmuller. 2008. Systems biology of JAK/STAT signalling. Essays Biochem. 45:109–120.

Schindler, C., D. E. Levy, and T. Decker. 2007. JAK-STAT signaling: from interferons to cytokines. J. Biol. Chem. 282:20059–20063.

Receptor Tyrosine Kinases

Lemmon, M. A., and J. Schlessinger. 2010. Cell signaling by receptor tyrosine kinases. Cell 141:1117–1134.

Lemmon, M., J. Schlessinger, and K. Fergusun, eds. 2014. The EGFR family: not so prototypical receptor tyrosine kinases. Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a020768.

Levitzki, A. 2013. Tyrosine kinase inhibitors: views of selectivity, sensitivity, and clinical performance. Annu. Rev. Pharmacol. 53:161–85.

Tomas, A., C. Futter, and E. Eden. 2014. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 24:26–34.

The Ras/MAP Kinase Pathway

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Gastel, M. 2006. MAPKAP kinases—MKs—two’s company, three’s a crowd. Nat. Rev. Mol. Cell Biol. 7:211–224.

Matallanas, D., et al. 2011. Raf family kinases: old dogs have learned new tricks. Genes Cancer 3:232–260.

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Phosphoinositide Signaling Pathways

Fayard, E., et al. 2010. Protein kinase B PKB/Akt, a key mediator of the PI3K signaling pathway. Curr. Top. Microbiol. 346:31–56.

Michell, R. H., et al. 2006. Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem. Sci. 31:52–63.

Vogt, P. K., et al. 2010. Phosphatidylinositol 3-kinase: the oncoprotein. Curr. Top. Microbiol. Immunol. 347:79–104.

Signaling Pathways Controlled by Ubiquitinylation and Protein Degradation: Wnt, Hedgehog, and NF-κB

Briscoe, J., and P. Thérond. 2013. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat. Rev. Mol. Cell Biol. 14:416–429.

Goetz, S., and K. Anderson. 2010. The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 11:331–344.

Iwai, K., et al. 2014. Linear ubiquitin chains: NF-κB signalling, cell death and beyond. Nat. Rev. Mol. Cell Biol. 15:503–508.

Nehers, C. 2012. The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 13:767–779.

Wan, F., and M. Lenardo. 2010. The nuclear signaling of NF-κB: current knowledge, new insights, and future perspectives. Cell Res. 20:24–33.

Signaling Pathways Controlled by Protein Cleavage: Notch/Delta, SREBP, and Alzheimer’s Disease

Anderson, P., et al. 2012. Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol. 22:257–265.

Brown, M. S., and J. L. Goldstein. 2009. Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J. Lipid Res. 50:S15–S27.

Musse, A., et al. 2012. Notch ligand endocytosis: mechanistic basis of signaling activity. Semin. Cell Dev. Biol. 23:429–436.

Integration of Cellular Responses to Multiple Signaling Pathways: Insulin Action

Bogan, J. 2012. Regulation of glucose transporter translocation in health and diabetes. Annu. Rev. Biochem. 81:507–532.

Leto, D., and A. Saltiel. 2012. Regulation of glucose transport by insulin: traffic control of GLUT4. Nat. Rev. Mol. Cell Biol. 1:383–396.

Rosen, E., and O. MacDougald. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7:885–896.