In 1525 Huayna Capac Inca, the grandson of Pachacuti Inca, became ill while carrying out a military campaign in present-day Ecuador, at the northern frontier of the empire. His illness was plague, introduced by Europeans waging wars of conquest in Mesoamerica, and it would kill him. But as he waged war, he also received news of the foreigners in the north and anticipated that they would come southward. From his deathbed, he urged his successor to make peace with them.

But peace did not follow Huayna Capac’s death. Instead civil war erupted between two of his sons over succession to the throne. Huascar claimed it as the firstborn. His half-brother Atahualpa, Huayna Capac’s favorite and an experienced military commander who had accompanied him in his Ecuadorean campaign, claimed it as well. The brothers fought for seven years, turning the empire’s armies against each other. In 1532 Atahualpa vanquished and imprisoned his brother and consolidated his rule in Cuzco. That same year a group of Spaniards led by Francisco Pizarro landed on the Peruvian coast, pursuing rumors of a city of gold in the mountains.

Atahualpa agreed through emissaries to meet the Spaniards at the city of Cajamarca in northern Peru. In a demonstration of his imperial authority, he entered Cajamarca carried on a golden litter, accompanied by four military squadrons of eight thousand men each. Atahualpa met the Spanish intending not to fight a battle, but to understand them and hear them out. The meeting between Atahualpa and Pizarro reflected two deeply different worldviews.

In the scuffle that ensued at the meeting, the Spaniards took Atahualpa prisoner, and they eventually executed him. The Spaniards named a new indigenous leader, Manco Capac, whom they hoped to control. But Manco Capac turned against the Spaniards. He, and later his son Tupac Amaru, led resistance against the Spaniards until 1567. Each time the Inca forces besieged a Spanish-controlled city or town, however, their proximity to the Spaniards exposed them to European diseases. They were more successful in smaller-scale attacks, which delayed and limited Spanish colonization, but did not undo it.