Decisive breakthroughs in astronomy and physics in the seventeenth century demolished the medieval synthesis of Aristotelian philosophy and Christian theology. The impact of these scientific breakthroughs on intellectual life was enormous, nurturing a new critical attitude in many disciplines. In addition, an international scientific community arose, and state-sponsored academies, which were typically closed to women, advanced scientific research.

Believing that all aspects of life were open to debate and skepticism, Enlightenment thinkers asked challenging questions about religious tolerance, representative government, and racial and sexual difference. Enlightenment thinkers drew inspiration from the new peoples and cultures encountered by Europeans and devised new ideas about race as a scientific and biological category. The ideas of the Enlightenment inspired absolutist rulers in central and eastern Europe, but real reforms were limited.

In the second half of the eighteenth century agricultural reforms helped produce tremendous population growth. Economic growth and urbanization favored the spread of Enlightenment thought by producing a public sphere in which ideas could be debated. The expansion of transatlantic trade made economic growth possible, as did the lowering of prices on colonial goods due to the growth of slave labor. Atlantic trade involved the exchange of commodities among Europe, Africa, and the Americas, but it was also linked with trade in the Indian and Pacific Oceans. The movement of people and ideas across the Atlantic helped shape the identities of colonial inhabitants.