Primary active transport uses the energy of ATP.

Passive transport works to the cell’s advantage only if the concentration gradient is in the right direction, from higher on the outside to lower on the inside for nutrients that the cell needs to take in, and from higher on the inside and lower on the outside for wastes that the cell needs to export. However, many of the molecules that cells require are not highly concentrated in the environment. Although some of these molecules can be synthesized by the cell, others must be taken up from the environment. In other words, cells have to move these substances from areas of lower concentration to areas of higher concentration. The “uphill” movement of substances against a concentration gradient, called active transport, requires energy. The transport of many kinds of molecules across membranes requires energy, either directly or indirectly. In fact, most of the energy used by a cell goes into keeping the inside of the cell different from the outside, a function carried out by proteins in the plasma membrane.

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During active transport, cells move substances through transport proteins embedded in the cell membrane. Some of these proteins act as pumps, using energy directly to move a substance into or out of a cell. A good example is the sodium-potassium pump (Fig. 5.12). Within cells, sodium is kept at concentrations much lower than in the exterior environment; the opposite is true of potassium. Therefore, both sodium and potassium have to be moved against a concentration gradient. The sodium-potassium pump actively moves sodium out of the cell and potassium into the cell. This movement of ions takes energy, which comes from the chemical energy stored in ATP. Active transport that uses energy directly in this manner is called primary active transport. Note that the sodium ions and potassium ions move in opposite directions. Protein transporters that work in this way are referred to as antiporters. Other transporters move two molecules in the same direction, and are referred to as symporters or cotransporters.

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FIG. 5.12 Primary active transport. The sodium-potassium pump is a membrane protein that uses the energy stored in ATP to move sodium and potassium ions against their concentration gradients.