Gene Nonsynonymous Rate (per site per 109 years) Synonymous Rate (per site per 109 years)
α-Actin      0.01      3.68
β-Actin      0.03      3.13
Albumin      0.91      6.63
Aldolase A      0.07      3.59
Apoprotein E      0.98      4.04
Creatine kinase      0.15      3.08
Erythropoietin      0.72      4.34
α-Globin      0.55      5.14
β-Globin      0.80      3.05
Growth hormone      1.23      4.95
Histone 3      0.00      6.38
Immunoglobulin heavy chain (variable region)      1.07      5.66
Insulin      0.13      4.02
Interferon α 1      1.41      3.53
Interferon γ      2.79      8.59
Luteinizing hormone      1.02      3.29
Somatostatin-28      0.00      3.97
Source: After W. Li and D. Graur, Fundamentals of Molecular Evolution (Sunderland, Mass.: Sinauer, 1991), p. 69, Table 1.
Table 26.4: Rates of nonsynonymous and synonymous substitutions in mammalian genes based on human-rodent comparisons