Chapter 14

Articles on ethical issues in genetics are preceded by an asterisk.

Akst, J. 2012. Targeting DNA. The Scientist, June 1: 36–42.

A review of the current state of gene therapy.

*Andrews, L. B., J. E. Fullarton, N. A. Holtzman, and A. G. Molulsky. 1994. Assessing Genetic Risks: Implications for Health and Social Policy. Washington, D.C.: National Academy Press.

A discussion of some of the legal, ethical, and social issues surrounding genetic testing.

Biber, F. R., C. H. Brenner, and D. Lazer. 2006. Finding criminals through DNA of their relatives. Science 312:1315–1316.

An interesting policy article on the use of DNA methods to find criminals through the identification of their relatives.

Butler, J. M., and C. R. Hill. 2012. Biology and genetics of new autosomal STR loci useful for forensic DNA analysis. Forensic Science Review 24:16–26.

A review of STR loci used in forensic investigations.

Cavazzana-Calvo, M., A. Thrasher, and F. Mavilio. 2004. The future of gene therapy. Nature 427:779–781.

A good review of gene therapy.

Cohen, S., A. Chang, H. Boyer, and R. Helling. 1973. Construction of biologically functional bacterial plasmids in vitro. Proceedings of the National Academy of Sciences of the United States of America 70:3240–3244.

A description of the first gene-cloning experiments.

Dykxhoorn, D. M., and J. Lieberman. 2006. Knocking down disease with siRNAs. Cell 126:231–235.

A review of the use of small interfering RNAs for treating diseases.

Gasser, C. S., and R. T. Fraley. 1992. Transgenic crops. Scientific American 266(6): 62–69.

An excellent and readable account of how genes are put into plants and some of the applications.

Hutchinson, W. D., E. C. Burkness, P. D. Mitchell, et al. 2010. Areawide suppression of European corn borer with Bt maize reaps savings to non-Bt maize growers. Science 330:222–225.

Scientific study of the effects of Bt corn on a common pest.

Lu, Y., Wu, K., Jiang, Y., et al. 2012. Widespread adoption of Bt cotton and insecticide decrease promotes biocontrol services. Nature 487:362–365.

Research report that Bt cotton promotes natural insect predators.

Lyall, J., R. M. Irvine, A. Sherman, et al. 2011. Suppression of avian influenza transmission in genetically modified chickens. Science 331:223–225.

Report of the development of transgenic chickens that are resistant to avian influenza virus.

Maguire, A. M., F. Simonelli, E. A. Pierce, et al. 2008. Safety and efficacy of gene transfer for Leber’s congenital amaurosis. New England Journal of Medicine 358:2240–2248.

A research report of the results of gene therapy for blindness caused by Leber congenital amaurosis.

Mak, T. W. 2007. Gene targeting in embryonic stem cells scores a knockout in Stockholm. Cell 131:1027–1031.

Reports on the awarding of the Nobel Prize in Physiology or Medicine to scientists who developed techniques for making knockout mice.

Moellar, L., and K. Wang. 2008. Engineering with precision: tools for the new generation of transgenic crops. BioScience 58:391–401.

A review of methods being used to create transgenic plants.

Mullis, K. B. 1990. The unusual origin of the polymerase chain reaction. Scientific American 262(4): 56–65.

Describes Mullis’s inspiration for the polymerase chain reaction.

Naldini, L. 2009. A comeback for gene therapy. Science 326:805–806.

A brief commentary on results of gene therapy for X-linked adrenoleukodystrophy.

Nowak, R. 1994. Forensic DNA goes to court with O. J. Science 265:1352–1354.

A report on the use of DNA fingerprinting in the famed O. J. Simpson trial.

Raney, T., and P. Pingali. 2007. Sowing a gene revolution. Scientific American 297(3): 104–111.

A discussion of the challenges of using genetic engineering to boost food production.

Riordan, J., J. M. Rommens, B. Kerem, et al. 1989. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066–1073.

A report on research that led to the identification of the gene that causes cystic fibrosis.

R16

Rommens, J. M., M. C. Iannuzzi, B. Kerem, et al. 1989. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245:1059–1065.

An additional report on research that led to the identification of the gene that causes cystic fibrosis.

Rossi, J. J. 2009. New hope for a microRNA therapy for liver cancer. Cell 137:990–992.

A report on research in which miRNA was used to treat liver cancer in mice.

Smith, M. D., F. Asche, A. G. Guttormsen, et al. 2010. Genetically modified salmon and full impact assessment. Science 330:1052–1053.

A comment by scientists on assessing the impact of genetically modified salmon.

Strauss, S. H. 2003. Genomics, genetic engineering, and domestication of crops. Science 300:61–62.

A discussion of some of the benefits and risks of the genetic engineering of agricultural crops.

Vaeck, M., A. Reynaerts, H. Hofte, et al. 1987. Transgenic plants protected from insect attack. Nature 328:33–37.

A research report on the first transfer of the gene for the Bt toxin into tobacco plants.

Von Bubnoff, A. 2008. Next generation sequencing: the race is on. Cell 132:721–723.

A commentary on new methods of rapidly sequencing DNA.

Wofenbarger, L. L., and P. R. Phifer. 2000. The ecological risks and benefits of genetically engineered plants. Science 290:2088–2093.

A review of scientific evidence of benefits and risks associated with the use of genetically engineered organisms in agriculture.

Yan, H., K. W. Kinzler, and B. Vogelstein. 2000. Genetic testing: present and future. Science 289:1890–1892.

A review of some of the problems associated with genetic testing and techniques being developed to overcome them.

Zanjani, E. D., and W. F. Anderson. 1999. Prospects for in utero human therapy. Science 285:2084–2088.

A review of the potential use of gene therapy in utero on unborn fetuses to correct human genetic defects.

Zimmermann, T. S., A. C. Lee, A. Akinc, et al. 2006. RNAi-mediated gene silencing in non-human primates. Nature 441:111–114.

A report on the use of RNA interference to lower cholesterol in monkeys.