5.2 Linked Genes Segregate Together, While Crossing Over Produces Recombination Between Them

Genes that are close together on the same chromosome usually segregate as a unit and are therefore inherited together. However, genes occasionally switch from one homologous chromosome to the other through the process of crossing over (see Chapter 2), as illustrated in Figure 5.3. Crossing over results in recombination; it breaks up the associations of genes that are close together on the same chromosome. Linkage and crossing over can be seen as processes that have opposite effects: linkage keeps particular genes together, and crossing over mixes them up, producing new combinations of genes. In Chapter 4, we considered a number of exceptions and extensions to Mendel’s principles of heredity. The concept of linked genes adds a further complication to interpretations of the results of genetic crosses. However, with an understanding of how linkage affects heredity, we can analyze crosses for linked genes and successfully predict the types of progeny that will be produced.

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Figure 5.3: Crossing over, which takes place in meiosis, is responsible for recombination.