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1480	Portuguese ships reach Congo.
1488	Bartolomeu Dias rounds Cape of Good Hope.
1492	Christopher Columbus lands in the Caribbean.
1493	Columbus’s second voyage to New World.
1494	Treaty of Tordesillas.
1497	John Cabot searches for Northwest Passage.
1498	Vasco da Gama sails to India.
1513	Vasco Núñez de Balboa crosses Isthmus of Panama.
1517	Protestant Reformation begins in Germany.
1519	Hernán Cortés searches for wealth in Mexico. Ferdinand Magellan sets out to sail around the world.
1520	Mexica in Tenochtitlán revolt against Spaniards.
1521	Cortés conquers Mexica.
1532	Francisco Pizarro begins conquest of Peru.
1535	Jacques Cartier explores St. Lawrence River.
1539	Hernando de Soto explores southeastern North America.
1540	Francisco Vásquez de Coronado starts to explore Southwest and Great Plains.
1542	Juan Rodríguez Cabrillo explores California coast.
1549	Repartimiento reforms replace encomienda.
1565	St. Augustine, Florida, settled.
1576	Martin Frobisher explores northern Canadian waters.
1587	English settle Roanoke Island.
1598	Juan de Oñate explores New Mexico.
1599	Acoma pueblos revolt against Oñate.