Figure 7.10 The concerted model for allosteric enzymes. (A) [T] >>> [R], meaning that L0 is large. Consequently, it will be difficult for S to bind to an R form of the enzyme. (B) As the concentration of S increases, it will bind to one of the active sites on R, trapping all of the other active sites in the R state (by the symmetry rule.) (C) As more active sites are trapped in the R state, it becomes easier for S to bind to the R state. (D) The binding of S to R becomes easier yet as more of the enzyme is in the R form. In a velocity-versus-[S] curve, V0 will be seen to rise rapidly toward Vmax.