PROBLEMS

Question 24.1

EmK+4Bdwi/RnfQcde49dXJO2FjJeSC3/4u1HVbsEojqLZOMghGAye8BeHbRMS3HxnOaw6Kwc+hhdDRsil0o7YLLE4uqqioKKMC7P5esfUmocqk6CgfF0mriRV/VjwXiQGXQbjC0m/IhQuPvSCcdnBYN6bhKyAL5HhzQ5EJUnLRzUtmho12bzlEex9CKbDTjYy4F3/lsMgEIxfHRyXXo4pp0Ic4vkD2sH/lplg8TCAX9DfTv84eFFpKvW6XqoWS5AnmZFIxTIPDOKk9zlXTERrrdYugnBkhkE6hxQtPhbbQ6B/dsf0NhzygiZ7Tu0iKCQyeZlfvepm+l8x+XZF4A+6/spwBZOYecGDEvyQg==

Question 24.2

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

Question 24.3

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Question 24.4

S/tyfyZNq358C9hCdD1/gLqHCFlv3Oab2bks3NcJ/fLTooHDqhx9LCUWA7nDZDuuUEn+X1uPbLkl6K7DJgF9FuMi9fenIxawiBqMaMK79FXFM/zGeZ1v1IrPxeKTGYCIXkT4c/rl3okBjkgPnBVK/HFvkexeeqP5EKOAZUTzINuq7Y0iRWZVQhwgwFTlrwyRH4/7UKgCpUbXhJuhlD2ybfo/IEVdZy5jESkcBPKFCQmyi6FWuDsZNscwiee8g7dOlcUpq/SG/TsFjWgS

Question 24.5

Eqp7d/8vIowRAsrW+729M36kAhzwHTkb1cm+ug8xuQ3LIAOK+QU+rSePO8fSrOVP6UKjjp16ILa6fBzWKHg+8w3Bj1hl/Ls2KJJ0nL/pFhfoAor8LD7Qwu4QX7mt8uP2xcZMkG7R1WgPr4ETxysZTJNkUchnoYwr0yynpBWPtm2dRRCYNxS4sDnzWNaK74TsYZqsHsodtM5Y83TY

Question 24.6

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

Question 24.7

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Question 24.8

nsNPMHV0x8EXHK7wcQUZwn6CMIuYCMnIfdtA3uxJf7X7A+vtakMShD7L3FxRhouWzpKD8ohAX6Zj2476qspPbZ6GD/79CMpPxUI4QNcZdP0D3OiAtxGVFNVyOxbmodHwZz/EQGkzEg8tfBHyIqqrYnWAOUYfqCFJ8BbFgKY7NCld1BXKIJy1KmEm7jqgTAEDSb09QBBanrT89V6OM8M6H1W0rx8YcVucWyLtyewvDp3uOay3LiQWyrC4/pCx/rDlhVCrtepKTryAhhE5LJ1cqkpsWhbQGZTSNsnOJXLEezTkwH4DtXqOZyIqt2w8+C57S1xtoUvbJxBz8tsRoa/ZHmFLfzpmCD1hR0KbZLaT45kMFD9xrcpnsu5ucZmp0Te51yC7ozmrmKJHn9Islo6TZJTfZYph3CBrQhhANmzJHPchSk+k/2CO0xo+U9G+njsQ4E0PguTGetj2QUhw2W4OMhWYJicesPxe

Question 24.9

olJFG3/HiwRSu3vR9rjPITU80bz0Qn76bdXKNG4t3advxe08NZzlSW75FfOlWokn5y5P93dy9mJXe5O+qJU7OebZq87MNcgeTo/V0mR7tDGZ12qOLbdnytPSGKsygOS/OycyRyE7HJEOhiiPYHqStDx7mfjF9T+WldbT0MO9rq8rSmHOMFhqpiVE22Tsz5QoZPiLDzEmdu4tf4/pNJWbi/PKblefe6pvQ1Ohj9R1wmUPODEx4SryRYG2RPIrtOQKeBBhEimu6rgpNFr6hV4HsinwWJTK2hzAwlQYfUjYOycdo0ytZ9aDmUn2F22MJfNXgRhVlw==

Question 24.10

Pxh2Ev+hwChnQu6i4qxQ3HuE0Vn01MdzAwe4a9hr6RwRm/UjyPoLusQK/8/oy4axpBswafplHw8ghmpVXBuFV/XE2A6a3q7cwuB6smWNgsae3HFrFgnsvQQLaf5ta1uzQj2R/mCNE7e8T71ilBxB+0K36xxgcaCwDcWbBnG3eijkGBZWfaQSV55Ywctc6XN/+9HuHWOYSV4ZHgv1U0f9kSMZprL4btY5AU3RuxK7K4d62DlujvSHTlXKkr7iB8HnGsEX3iUTpnPAFGK2YkqJHBHW5BS45sa3

Question 24.11

TnK20xIvV0WRz8byTxv3mshpLlc8a5vR8wke2cLtjuXT7eMJYhieqSkvBhlA6X/ZUdLQF6eOs1eZ0NC7/B0xrA39ehmXoocsMgMa8O5fH5snJd7lRwS3nTW/iADw4SY7T7YqCqZoN8BvAsOwdz5ljPJFxw0I5HA7OrFL81YIrF94wSKfcHeeLiXQU6cX21wIIf3KRUZLomcaiLoNKjUjdELk3v3hCMYnVJoKlOQbw83TFy8FxfN1G8RENoG+NWqX4sxUPv004CDmkLx+3GlxilSg1IZJyKCwWAaiakPaEaxZpTCQaVIk/rkT1jCaFaKJ

Question 24.12

Fl61vGPqFTBoZiuB/XE6MP3QAMecu4EUKuny1UlQZ4q0LUyrpT8BAE1/lcuPJAix4y/E/vnMc8sXbZtBJhff2PUTrUl8AKAgWYrnqelKevCt4KQXps2WxKFdjKGyuzvX08kbyuCFwNUY1AW3a9hRl459lzr+uhuWlHCbFYcxyLqR/wVCUF1O1/fArm/I4HJbK5Sy/BX0lV4JPGjufBoVe1di/BhsV3TvYODFearjBYUOojyUGrp1/Sk3G4RTYw3hrpkMAEuyoTgFKezJxv3RZ6C1UwaNfXWJoGFTMrauuac5p1vNQ4CSpU8MjuRBFnNQdyK5s3azc4ZCOMfIlZIGTuDhSBcyfCP/VmySZ2sgJkRgQHLLGwoFA/fBq5WYbG1J

Question 24.13

H4Rw+ZYF/sS7OMtWw4JtaoZMOLmbXXQUp/RFDkb7+L86kqzAPE2WbHZdpItshm1HX7y8x6bb5peMP/k0yMM3Hyo0XmQCioZICCkFrFl5BBXHxmEZvFY2owa0K2Ndb9i5slnoyGLnQ1IKzuxDBXDGdMWZPaaCytzZMmLym+o5KwVvjuqXKuCcLpi3B2tMZ/+76HvrPHkcYNW0X6H2up1fMi7YJe+gRmXsYbbECutR3qzNoxh9gEbm3RrvGGqKSMSuizq0lsqyY4xeidk9L6GldA==

Question 24.14

GRg4QvV4il1Nw13gvk1I4y9Nq2ItXpiy8bE0xM1tT5dZge2kOJCdY+epmrKm3IV5MSQVDd/LwDcQgSRyJeVKD8+5vSb9H0Tg1vuxgYsUnECJz6O2W6jQfYmx4bDpgxxVJUxeyJKYvQtd4313/AyeJQ8vDtweGNJLi7cWq/cupNpvnvMdWbnjVJKY00+eo4jtMYyoIxCtfMAI+eLJWm3Sa+sNUOcPqIM8Sb3v4XM1kZlCJrnedXLjMSXUOtHR+ijlVeMMGoDawmy36iyoaCu1fpMqykJnIyB85MVKM2lhaUBoTDqGQo7kmNoF4jBuNxCO8derSTzDVR/rXb2IV7EGfWfOq7TEBZkSaBUgnfJCyaVJVDqX36fr1BSbH4M=

Question 24.15

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

Question 24.16

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

Question 24.17

LmVTpacJyYRjWwecGZYB43d9K+WS6VZ40uvuLhDa4w5xZZu4eszKJ1micIAJfqZsjWZLsVx8DiYyiycFZcqt8nusxzsy63wAwFqIhpA+I266qVgd8kfonl+MRoMhEo54e1UBsYU7Ls1wfuzgSFt0bW7Ces3+EktdX9ybjoHBZ8ag97j3hEoyO6FRzUXKhlC+/KA5yDsqWc9ehqZFfOVXAYTIksHTyqr1LadEmJxExabACYuxaV5Zj+utljjA21ffWPaJDg==

Question 24.18

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Question 24.19

R and T, a and b. Glycogen phosphorylase can exist in the following states. ✓ 2

A. Phosphorylase a

T state

B. Phosphorylase a

R state

C. Phosphorylase b

T state

D. Phosphorylase b

R state

(a) Which forms of the enzyme are most active?

(b) What enzyme catalyzes the C-to-A conversion?

(c) In muscle, high concentrations of AMP cause a transition between what two forms?

(d) In liver, the transition between what two forms is stimulated by glucose?

(e) In muscle, which transition is stimulated by glucose 6-phosphate?

(f) What enzyme converts A into C?

46O/GvlXlao=
R and T, a and b. Glycogen phosphorylase can exist in the following states. ✓ 2 (a) Which forms of the enzyme are most active? (b) What enzyme catalyzes the C-to-A conversion? (c) In muscle, high concentrations of AMP cause a transition between what two forms? (d) In liver, the transition between what two forms is stimulated by glucose? (e) In muscle, which transition is stimulated by glucose 6-phosphate? (f) What enzyme converts A into C?

Question 24.20

fyHdtKafmRQagu2cG3vmPBABwvvTZWLJUzX9djjutvjgJJC2YIYQkSRbtVimj4cmeQ52SSa357QB5+gURULM3ZUWKkX9eP6ViDB9+iIWZSu38lCmfJAH/uvSUR94QKNi+GMlfgKv61J/tcCyH7Xu96OHTiN/185ZyfyyNIWZf4x093oiCIfSNUWkIkr2wAnJBd0BWOVNT2x3jagwiGg7uCn2rOH+hItYVkjA/TFULtvCCnd/JYYQBiVx1ioF/34rb5R8wA==

Question 24.21

SzfZboIb36UleKS4cpfzfSEQjGIKqOGEbWWApHx5uWbWyMKpKHLqmKKkS2VrNLtRyqftkM8UcaQnl+rWztJOuwSGeBLvSDjP5kT9BOoFb0S7SY2Q0cYg+lVAMAbWC7qMeYDpOPXAtMkwy1jAImmuDvmUus6S/FQBdRAVUOMPrA0TMRDwyWGF0kvB+RG0XYJlezRh+Q2G6ckqIA2RUPa4vi3dBNpJf/u/6TGrZE0loFCKLatMaLY6reVIQc31ebuuOKW8zp1xcCHkDDaPBFx7LCLZBRyUqN8rfArvvTan+TY7BtpT6JyG+Lli5QMG0uxQumBlT8N/SvYjeme9yGJ5y/7B0xTT3R+zS/N0EZMcsG1DIRryGSZ/dhtq96IGbAYIumX0iA==

Chapter Integration and Challenge Problems

Question 24.22

KY1xteAoWy1Z/ujBCU6n1cE7hgaMKUZkVPiCnUvDDy/GlBlbfi7j3P7d0zw6B8G+QIXOqOvfhxJ4sREzRPb8zWodLoqscaH5ww4h3HIpKh20Csd8n0bgmp3NCfxU0SjIHf2dMfr8MFNLyDXry9Ll8QVpYkcGPeGiJWDCxaqqiG6rMstk7aplTsftNsqkyj6akjSK/VGd6WZIQZvl5tp8MI9IMbhTcLp6PVwGV2BkSCHsxKn63kVZp7LumCbh/esoIMunEA/XrSAAKdz+f9VQr/gapkrmmPJgCp/5SR6DnoOMRwk+ipcvRdT1IyJLU1fK0TEK0CweLJ34Er66Kq95OXFw5yWV5kWJcfslIh/r+4c=

Question 24.23

D2xoZqSDuSH8Bg7npy1zF8VZDMb4ZHK0z2Vt/Q7EoeXS7DE72HJPfI0YB8Cucl0ChGUuHmf93mrxS1/9X15lT2DUhEeqjrG1RzrCHzF7Wz1ew7qSl8iGEzS5ol5k5ZbxAJYA3xDWZefHFdKwxXYXbEWGqeFUBz04tUzsQRHeRcYh3yWrCv7LjuUM64kc66QhTV40ZYhog/vn9pDzUWA/Ez9gKePpQ6IQ6Nm8GYdgy+yO1FX/Zdavff6jPyW15JCgDA9j0vGb3iHAiZAYnN1mX4LP85lzgzj/GIGssmNX2wxvrFQ64iayNw==

Question 24.24

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

Question 24.25

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

Question 24.26

Atn7+r+JwP8z5zQXv3cii+ylU2E7Jb8iIAE04k6QmxI0qTPHZVdpzCAXvEvCi+wY+yQw6kNtFqI9nhkFbNy8+hVbSTf74ihsEo+OYS5kqPuo+gm+FVA1Co0eRx+CXeAKNfvmnKX31zMc8OHnY/vEqywJtNXUim6S2V16ORgEVkHJDyD2bWcAkA/zjrs6zoqRIJkJcmg+ps0nQMotv/W6Kw==

Question 24.27

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

Data Interpretation Problem

Question 24.28

An authentic replica. Experiments were performed in which serine (S) 14 of glycogen phosphorylase was replaced by glutamate (E). The Vmax of the mutant enzyme was then compared with the wild-type phosphorylase in both the a and the b forms.

 

Vmax μmol of glucose 1-PO4 released min−1 mg−1

Wild-type phosphorylase b

25 ± 0.4

Wild-type phosphorylase a

100 ± 5     

S to E mutant

60 ± 3   

(a) Explain the results obtained with the mutant.

(b) Predict the effect of substituting aspartic acid for the serine.

46O/GvlXlao=
An authentic replica. Experiments were performed in which serine (S) 14 of glycogen phosphorylase was replaced by glutamate (E). The V max of the mutant enzyme was then compared with the wild-type phosphorylase in both the a and the b forms. (a) Explain the results obtained with the mutant. (b) Predict the effect of substituting aspartic acid for the serine.

Selected Readings for this chapter can be found online at www.whfreeman.com/tymoczko3e.