Brief Contents

PART I The Molecular Design of Life

SECTION 1 Biochemistry Helps Us Understand Our World

1

Chapter 1 Biochemistry and the Unity of Life

3

Chapter 2 Water, Weak Bonds, and the Generation of Order Out of Chaos

17

SECTION 2 Protein Composition and Structure

35

Chapter 3 Amino Acids

37

Chapter 4 Protein Three-Dimensional Structure

47

Chapter 5 Techniques in Protein Biochemistry

69

SECTION 3 Basic Concepts and Kinetics of Enzymes

95

Chapter 6 Basic Concepts of Enzyme Action

97

Chapter 7 Kinetics and Regulation

111

Chapter 8 Mechanisms and Inhibitors

131

Chapter 9 Hemoglobin, an Allosteric Protein

149

SECTION 4 Carbohydrates and Lipids

165

Chapter 10 Carbohydrates

167

Chapter 11 Lipids

189

SECTION 5 Cell Membranes, Channels, Pumps, and Receptors

203

Chapter 12 Membrane Structure and Function

205

Chapter 13 Signal-Transduction Pathways

225

PART II Transducing and Storing Energy

SECTION 6 Basic Concepts and Design of Metabolism

245

Chapter 14 Digestion: Turning a Meal into Cellular Biochemicals

247

Chapter 15 Metabolism: Basic Concepts and Design

257

SECTION 7 Glycolysis and Gluconeogenesis

281

Chapter 16 Glycolysis

283

Chapter 17 Gluconeogenesis

313

SECTION 8 The Citric Acid Cycle

329

Chapter 18 Preparation for the Cycle

331

Chapter 19 Harvesting Electrons from the Cycle

343

SECTION 9 Oxidative Phosphorylation

361

Chapter 20 The Electron-Transport Chain

363

Chapter 21 The Proton-Motive Force

383

SECTION 10 The Light Reactions of Photosynthesis and the Calvin Cycle

405

Chapter 22 The Light Reactions

407

Chapter 23 The Calvin Cycle

427

SECTION 11 Glycogen Metabolism and the Pentose Phosphate Pathway

443

Chapter 24 Glycogen Degradation

445

Chapter 25 Glycogen Synthesis

459

Chapter 26 The Pentose Phosphate Pathway

473

SECTION 12 Fatty Acid and Lipid Metabolism

487

Chapter 27 Fatty Acid Degradation

489

Chapter 28 Fatty Acid Synthesis

507

Chapter 29 Lipid Synthesis: Storage Lipids, Phospholipids, and Cholesterol

523

SECTION 13 The Metabolism of Nitrogen- Containing Molecules

549

Chapter 30 Amino Acid Degradation and the Urea Cycle

551

Chapter 31 Amino Acid Synthesis

571

Chapter 32 Nucleotide Metabolism

585

PART III Synthesizing the Molecules of Life

SECTION 14 Nucleic Acid Structure and DNA Replication

605

Chapter 33 The Structure of Informational Macromolecules: DNA and RNA

607

Chapter 34 DNA Replication

627

Chapter 35 DNA Repair and Recombination

643

SECTION 15 RNA Synthesis, Processing, and Regulation

657

Chapter 36 RNA Synthesis and Regulation in Bacteria

659

Chapter 37 Gene Expression in Eukaryotes

675

Chapter 38 RNA Processing in Eukaryotes

691

SECTION 16 Protein Synthesis and Recombinant DNA Techniques

705

Chapter 39 The Genetic Code

707

Chapter 40 The Mechanism of Protein Synthesis

721

Chapter 41 Recombinant DNA Techniques

743

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