Chapter Introduction

CHAPTER 2

What Is the Nervous System’s Functional Anatomy?

33

RESEARCH FOCUS 2-1 AGENESIS OF THE CEREBELLUM

2-1 OVERVIEW OF BRAIN FUNCTION AND STRUCTURE

PLASTIC PATTERNS OF NEURAL ORGANIZATION

FUNCTIONAL ORGANIZATION OF THE NERVOUS SYSTEM

THE BRAIN’S SURFACE FEATURES

THE BASICS FINDING YOUR WAY AROUND THE BRAIN

CLINICAL FOCUS 2-2 MENINGITIS AND ENCEPHALITIS

THE BRAIN’S INTERNAL FEATURES

CLINICAL FOCUS 2-3 STROKE

2-2 THE NERVOUS SYSTEM’S EVOLUTIONARY DEVELOPMENT

STAGES IN BRAIN EVOLUTION

THE NERVOUS SYSTEM AND INTELLIGENT BEHAVIOR

EXPERIMENT 2-1 QUESTION: DOES INTELLIGENT BEHAVIOR REQUIRE A VERTEBRATE NERVOUS SYSTEM ORGANIZATION?

2-3 THE CENTRAL NERVOUS SYSTEM: MEDIATING BEHAVIOR

SPINAL CORD

BRAINSTEM

FOREBRAIN

CEREBRAL CORTEX

BASAL GANGLIA

LIMBIC SYSTEM

OLFACTORY SYSTEM

2-4 SOMATIC NERVOUS SYSTEM: TRANSMITTING INFORMATION

CRANIAL NERVES

SPINAL NERVES

SOMATIC NERVOUS SYSTEM CONNECTIONS

INTEGRATING SPINAL FUNCTIONS

CLINICAL FOCUS 2-4 MAGENDIE, BELL, AND BELL PALSY

2-5 AUTONOMIC AND ENTERIC NERVOUS SYSTEMS: VISCERAL RELATIONS

ANS: BALANCING INTERNAL FUNCTIONS

ENS: CONTROLLING THE GUT

2-6 TEN PRINCIPLES OF NERVOUS SYSTEM FUNCTION

PRINCIPLE 1: THE NERVOUS SYSTEM PRODUCES MOVEMENT IN A PERCEPTUAL WORLD THE BRAIN CONSTRUCTS

PRINCIPLE 2: NEUROPLASTICITY IS THE HALLMARK OF NERVOUS SYSTEM FUNCTIONING

PRINCIPLE 3: MANY BRAIN CIRCUITS ARE CROSSED

PRINCIPLE 4: THE CNS FUNCTIONS ON MULTIPLE LEVELS

PRINCIPLE 5: THE BRAIN IS SYMMETRICAL AND ASYMMETRICAL

PRINCIPLE 6: BRAIN SYSTEMS ARE ORGANIZED HIERARCHICALLY AND IN PARALLEL

PRINCIPLE 7: SENSORY AND MOTOR DIVISIONS PERMEATE THE NERVOUS SYSTEM

PRINCIPLE 8: THE BRAIN DIVIDES SENSORY INPUT FOR OBJECT RECOGNITION AND MOTOR CONTROL

PRINCIPLE 9: BRAIN FUNCTIONS ARE LOCALIZED AND DISTRIBUTED

PRINCIPLE 10: THE NERVOUS SYSTEM WORKS BY JUXTAPOSING EXCITATION AND INHIBITION

image
Katherine Streeter

34

RESEARCH FOCUS 2-1

Agenesis of the Cerebellum

When an adult’s brain is damaged, as for example in traumatic brain injury, we see a pattern of behavioral changes that offer insight into brain functions, as described by Fred Linge in Clinical Focus 1-1, Living with Traumatic Brain Injury. Naturally occurring brain injuries rarely remove a single structure completely, leaving the rest of the brain intact. However, agenesis, the failure of brain regions to develop, offers researchers a unique window on the brain’s organization and function, because in rare cases a complete structure is absent yet the rest of the brain appears normal.

Historically, the cerebellum was viewed as a motor structure, with the most obvious sign of damage being ataxia, a failure of muscular coordination and balance. But the cerebellum’s functions are much more extensive than movement control (e.g., Schmahmann, 2010). Adult patients with damage to the cerebellum do have motor disturbances, but they also have cognitive deficits, for example, in abstract thinking and language and in emotional control.

The cerebellum contains the most neurons of any brain region, accounting for 80 percent of the neurons in humans and a whopping 97.5 percent of elephants’ neurons—believed to be related to the dexterity of the elephant’s trunk. What would happen if the cerebellum failed to develop but the rest of the brain developed apparently normally? We humans would be missing 80 percent of our neurons!

The accompanying images contrast the brain of a young man born with agenesis of the cerebellum (A and B) to the brain of a person whose brain developed normally (C and D). Even lacking 80 percent of his neurons, the young man’s behavioral capacities are remarkable, but his behavior is not typical. Now in his thirties, he has an office job and lives alone. He has a distinctive speaking pattern, an awkward gait, and difficulties with balance, as well as deficits in planning and abstract thinking. His social skills and long-term memory are good, though, as is his mastery of routine activities.

Studies of other people with cerebellar agenesis reveal a heterogeneous set of symptoms, but neuropsychological assessments show behavioral deficits reminiscent of people with damage to frontal and parietal cortical regions (e.g., Baumann et al., 2015), even though these cerebral regions are intact. Although people with cerebellar agenesis develop slowly, they show remarkable improvement over time and seem able to compensate for many of their symptoms. The individual whose brain you see in images A and B had severe visuomotor spatial disabilities as a child and adolescent, but by age 30 he showed significant improvement (Chheda et al., 2002; Schmahmann et al., 2007; Jeremy D. Schmahmann and Janet C. Sherman, personal communication). Other patients’ language develops slowly.

image
MRI brain scans of a person with cerebellar agenesis (A, B) compared to a control person (C, D) of the same age. A and C are viewed in the coronal plane, B and D in the mid-sagittal plane. For more about this condition: www.npr.org/blogs/health/2015/03/16/393351760
Massachusetts General Hospital; Credit: Courtesy of Jeremy Schmahmann

In people with absence of the cerebellum it is thought that brain plasticity in response to early perturbations emerge as regions of the cerebral cortex begin to function more efficiently. In fact, it has been reported that cerebellar agenesis patients appear to have some of the symptoms of autism early in life. This observation comports with evidence that dysfunction (rather than absence) of the cerebellum is related to autism (detailed in Clinical Focus 8-2, Autism Spectrum Disorder).

Throughout this book we examine the nervous system with a focus on function—on how our behavior and our brain interact. In this chapter, we consider the human nervous system’s organization and how its basic components function in the context of plasticity, as illustrated in Research Focus 2-1, Agenesis of the Cerebellum. First, we emphasize the brain’s biology. Then we elaborate on function—how the brain works in concert with the rest of the nervous system. This focus on nervous system function and plasticity suggests 10 principles of nervous system organization. We note each principle through the chapter and in detail at its end, in Section 2-6. These big ideas apply equally to the micro and macro views of the nervous system presented in this chapter and to the broader picture of behavior that emerges in later chapters.