FileTitleManuscript Id
Chapter Introductionlodish8e_ch23_1.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_1_dlap.xml57335f7c757a2eec7e000001
23.1 Overview of Host Defenses lodish8e_ch23_2.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_2_dlap.xml57335f7c757a2eec7e000001
Pathogens Enter the Body Through Different Routes and Replicate at Different Sites lodish8e_ch23_3.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_3_dlap.xml57335f7c757a2eec7e000001
Leukocytes Circulate Throughout the Body and Take Up Residence in Tissues and Lymph Nodes lodish8e_ch23_4.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_4_dlap.xml57335f7c757a2eec7e000001
Mechanical and Chemical Boundaries Form a First Layer of Defense Against Pathogens lodish8e_ch23_5.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_5_dlap.xml57335f7c757a2eec7e000001
Innate Immunity Provides a Second Line of Defense lodish8e_ch23_6.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_6_dlap.xml57335f7c757a2eec7e000001
Inflammation Is a Complex Response to Injury That Encompasses Both Innate and Adaptive Immunity lodish8e_ch23_7.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_7_dlap.xml57335f7c757a2eec7e000001
Adaptive Immunity, the Third Line of Defense, Exhibits Specificity lodish8e_ch23_8.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_8_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.1lodish8e_ch23_9.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_9_dlap.xml57335f7c757a2eec7e000001
23.2 Immunoglobulins: Structure and Function lodish8e_ch23_10.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_10_dlap.xml57335f7c757a2eec7e000001
Immunoglobulins Have a Conserved Structure Consisting of Heavy and Light Chains lodish8e_ch23_11.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_11_dlap.xml57335f7c757a2eec7e000001
Multiple Immunoglobulin Isotypes Exist, Each with Different Functions lodish8e_ch23_12.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_12_dlap.xml57335f7c757a2eec7e000001
Each Naive B Cell Produces a Unique Immunoglobulin lodish8e_ch23_13.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_13_dlap.xml57335f7c757a2eec7e000001
Immunoglobulin Domains Have a Characteristic Fold Composed of Two β Sheets Stabilized by a Disulfide Bond lodish8e_ch23_14.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_14_dlap.xml57335f7c757a2eec7e000001
An Immunoglobulin’s Constant Region Determines Its Functional Properties lodish8e_ch23_15.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_15_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.2lodish8e_ch23_16.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_16_dlap.xml57335f7c757a2eec7e000001
23.3 Generation of Antibody Diversity and B-Cell Development lodish8e_ch23_17.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_17_dlap.xml57335f7c757a2eec7e000001
A Functional Light-Chain Gene Requires Assembly of V and J Gene Segments lodish8e_ch23_18.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_18_dlap.xml57335f7c757a2eec7e000001
Rearrangement of the Heavy-Chain Locus Involves V, D, and J Gene Segments lodish8e_ch23_19.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_19_dlap.xml57335f7c757a2eec7e000001
Somatic Hypermutation Allows the Generation and Selection of Antibodies with Improved Affinities lodish8e_ch23_20.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_20_dlap.xml57335f7c757a2eec7e000001
B-Cell Development Requires Input from a Pre-B-Cell Receptor lodish8e_ch23_21.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_21_dlap.xml57335f7c757a2eec7e000001
During an Adaptive Response, B Cells Switch from Making Membrane-Bound Ig to Making Secreted Ig lodish8e_ch23_22.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_22_dlap.xml57335f7c757a2eec7e000001
B Cells Can Switch the Isotype of Immunoglobulin They Make lodish8e_ch23_23.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_23_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.3lodish8e_ch23_24.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_24_dlap.xml57335f7c757a2eec7e000001
23.4 The MHC and Antigen Presentation lodish8e_ch23_25.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_25_dlap.xml57335f7c757a2eec7e000001
The MHC Determines the Ability of Two Unrelated Individuals of the Same Species to Accept or Reject Grafts lodish8e_ch23_26.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_26_dlap.xml57335f7c757a2eec7e000001
The Killing Activity of Cytotoxic T Cells Is Antigen Specific and MHC Restricted lodish8e_ch23_27.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_27_dlap.xml57335f7c757a2eec7e000001
T Cells with Different Functional Properties Are Guided by Two Distinct Classes of MHC Molecules lodish8e_ch23_28.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_28_dlap.xml57335f7c757a2eec7e000001
MHC Molecules Bind Peptide Antigens and Interact with the T-Cell Receptor lodish8e_ch23_29.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_29_dlap.xml57335f7c757a2eec7e000001
Antigen Presentation Is the Process by Which Protein Fragments Are Complexed with MHC Products and Posted to the Cell Surface lodish8e_ch23_30.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_30_dlap.xml57335f7c757a2eec7e000001
The Class I MHC Pathway Presents Cytosolic Antigens lodish8e_ch23_31.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_31_dlap.xml57335f7c757a2eec7e000001
The Class II MHC Pathway Presents Antigens Delivered to the Endocytic Pathway lodish8e_ch23_32.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_32_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.4lodish8e_ch23_33.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_33_dlap.xml57335f7c757a2eec7e000001
23.5 T Cells, T-Cell Receptors, and T-Cell Development lodish8e_ch23_34.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_34_dlap.xml57335f7c757a2eec7e000001
The Structure of the T-Cell Receptor Resembles the F(ab) Portion of an Immunoglobulin lodish8e_ch23_35.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_35_dlap.xml57335f7c757a2eec7e000001
TCR Genes Are Rearranged in a Manner Similar to Immunoglobulin Genes lodish8e_ch23_36.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_36_dlap.xml57335f7c757a2eec7e000001
Many of the Variable Residues of TCRs Are Encoded in the Junctions Between V, D, and J Gene Segments lodish8e_ch23_37.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_37_dlap.xml57335f7c757a2eec7e000001
Signaling via Antigen-Specific Receptors Triggers Proliferation and Differentiation of T and B Cells lodish8e_ch23_38.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_38_dlap.xml57335f7c757a2eec7e000001
T Cells Capable of Recognizing MHC Molecules Develop Through a Process of Positive and Negative Selection lodish8e_ch23_39.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_39_dlap.xml57335f7c757a2eec7e000001
T Cells Commit to the CD4 or CD8 Lineage in the Thymus lodish8e_ch23_40.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_40_dlap.xml57335f7c757a2eec7e000001
T Cells Require Two Types of Signals for Full Activation lodish8e_ch23_41.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_41_dlap.xml57335f7c757a2eec7e000001
Cytotoxic T Cells Carry the CD8 Co-receptor and Are Specialized for Killing lodish8e_ch23_42.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_42_dlap.xml57335f7c757a2eec7e000001
T Cells Produce an Array of Cytokines That Provide Signals to Other Immune-System Cells lodish8e_ch23_43.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_43_dlap.xml57335f7c757a2eec7e000001
Helper T Cells Are Divided into Distinct Subsets Based on Their Cytokine Production and Expression of Surface Markers lodish8e_ch23_44.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_44_dlap.xml57335f7c757a2eec7e000001
Leukocytes Move in Response to Chemotactic Cues Provided by Chemokines lodish8e_ch23_45.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_45_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.5lodish8e_ch23_46.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_46_dlap.xml57335f7c757a2eec7e000001
23.6 Collaboration of Immune-System Cells in the Adaptive Response lodish8e_ch23_47.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_47_dlap.xml57335f7c757a2eec7e000001
Toll-Like Receptors Perceive a Variety of Pathogen-Derived Macromolecular Patterns lodish8e_ch23_48.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_48_dlap.xml57335f7c757a2eec7e000001
Engagement of Toll-Like Receptors Leads to Activation of Antigen-Presenting Cells lodish8e_ch23_49.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_49_dlap.xml57335f7c757a2eec7e000001
Production of High-Affinity Antibodies Requires Collaboration Between B and T cells lodish8e_ch23_50.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_50_dlap.xml57335f7c757a2eec7e000001
Vaccines Elicit Protective Immunity Against a Variety of Pathogens lodish8e_ch23_51.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_51_dlap.xml57335f7c757a2eec7e000001
The Immune System Defends Against Cancer lodish8e_ch23_52.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_52_dlap.xml57335f7c757a2eec7e000001
Key Concepts of Section 23.6lodish8e_ch23_53.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_53_dlap.xml57335f7c757a2eec7e000001
Key Terms lodish8e_ch23_54.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_54_dlap.xml57335f7c757a2eec7e000001
Review the Concepts lodish8e_ch23_55.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_55_dlap.xml57335f7c757a2eec7e000001
Extended References lodish8e_ch23_56.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_56_dlap.xml57335f7c757a2eec7e000001
Perspectives for the Future lodish8e_ch23_57.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_57_dlap.xml57335f7c757a2eec7e000001
Classic Experiment 23-1: Two Genes Become One: Somatic Recombination of Immunoglobulin Geneslodish8e_ch23_58.html57335f7c757a2eec7e000001
DLAP questionslodish8e_ch23_58_dlap.xml57335f7c757a2eec7e000001