FileTitleManuscript Id
Chapter Introductionlodish8e_ch6_1.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_1_dlap.xml572b8933757a2e9c31000000
6.1 Genetic Analysis of Mutations to Identify and Study Genes lodish8e_ch6_2.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_2_dlap.xml572b8933757a2e9c31000000
Recessive and Dominant Mutant Alleles Generally Have Opposite Effects on Gene Function lodish8e_ch6_3.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_3_dlap.xml572b8933757a2e9c31000000
Segregation of Mutations in Breeding Experiments Reveals Their Dominance or Recessivity lodish8e_ch6_4.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_4_dlap.xml572b8933757a2e9c31000000
Conditional Mutations Can Be Used to Study Essential Genes in Yeast lodish8e_ch6_5.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_5_dlap.xml572b8933757a2e9c31000000
Recessive Lethal Mutations in Diploids Can Be Identified by Inbreeding and Maintained in Heterozygotes lodish8e_ch6_6.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_6_dlap.xml572b8933757a2e9c31000000
Complementation Tests Determine Whether Different Recessive Mutations Are in the Same Gene lodish8e_ch6_7.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_7_dlap.xml572b8933757a2e9c31000000
Double Mutants Are Useful in Assessing the Order in Which Proteins Function lodish8e_ch6_8.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_8_dlap.xml572b8933757a2e9c31000000
Genetic Suppression and Synthetic Lethality Can Reveal Interacting or Redundant Proteins lodish8e_ch6_9.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_9_dlap.xml572b8933757a2e9c31000000
Genes Can Be Identified by Their Map Position on the Chromosome lodish8e_ch6_10.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_10_dlap.xml572b8933757a2e9c31000000
Key Concepts of Section 6.1lodish8e_ch6_11.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_11_dlap.xml572b8933757a2e9c31000000
6.2 DNA Cloning and Characterization lodish8e_ch6_12.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_12_dlap.xml572b8933757a2e9c31000000
Restriction Enzymes and DNA Ligases Allow Insertion of DNA Fragments into Cloning Vectors lodish8e_ch6_13.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_13_dlap.xml572b8933757a2e9c31000000
Isolated DNA Fragments Can Be Cloned into E. coli Plasmid Vectors lodish8e_ch6_14.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_14_dlap.xml572b8933757a2e9c31000000
Yeast Genomic Libraries Can Be Constructed with Shuttle Vectors and Screened by Functional Complementation lodish8e_ch6_15.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_15_dlap.xml572b8933757a2e9c31000000
cDNA Libraries Represent the Sequences of Protein-Coding Genes lodish8e_ch6_16.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_16_dlap.xml572b8933757a2e9c31000000
The Polymerase Chain Reaction Amplifies a Specific DNA Sequence from a Complex Mixture lodish8e_ch6_17.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_17_dlap.xml572b8933757a2e9c31000000
Cloned DNA Molecules Can Be Sequenced Rapidly by Methods Based on PCR lodish8e_ch6_18.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_18_dlap.xml572b8933757a2e9c31000000
Key Concepts of Section 6.2lodish8e_ch6_19.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_19_dlap.xml572b8933757a2e9c31000000
6.3 Using Cloned DNA Fragments to Study Gene Expression lodish8e_ch6_20.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_20_dlap.xml572b8933757a2e9c31000000
Hybridization Techniques Permit Detection of Specific DNA Fragments and mRNAs lodish8e_ch6_21.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_21_dlap.xml572b8933757a2e9c31000000
DNA Microarrays Can Be Used to Evaluate the Expression of Many Genes at One Time lodish8e_ch6_22.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_22_dlap.xml572b8933757a2e9c31000000
Cluster Analysis of Multiple Expression Experiments Identifies Co-regulated Genes lodish8e_ch6_23.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_23_dlap.xml572b8933757a2e9c31000000
E. coli Expression Systems Can Produce Large Quantities of Proteins from Cloned Genes lodish8e_ch6_24.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_24_dlap.xml572b8933757a2e9c31000000
Plasmid Expression Vectors Can Be Designed for Use in Animal Cells lodish8e_ch6_25.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_25_dlap.xml572b8933757a2e9c31000000
Key Concepts of Section 6.3lodish8e_ch6_26.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_26_dlap.xml572b8933757a2e9c31000000
6.4 Locating and Identifying Human Disease Genes lodish8e_ch6_27.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_27_dlap.xml572b8933757a2e9c31000000
Monogenic Diseases Show One of Three Patterns of Inheritance lodish8e_ch6_28.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_28_dlap.xml572b8933757a2e9c31000000
DNA Polymorphisms Are Used as Markers for Linkage Mapping of Human Mutations lodish8e_ch6_29.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_29_dlap.xml572b8933757a2e9c31000000
Linkage Studies Can Map Disease Genes with a Resolution of About 1 Centimorgan lodish8e_ch6_30.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_30_dlap.xml572b8933757a2e9c31000000
Further Analysis Is Needed to Locate a Disease Gene in Cloned DNA lodish8e_ch6_31.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_31_dlap.xml572b8933757a2e9c31000000
Many Inherited Diseases Result from Multiple Genetic Defects lodish8e_ch6_32.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_32_dlap.xml572b8933757a2e9c31000000
Key Concepts of Section 6.4lodish8e_ch6_33.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_33_dlap.xml572b8933757a2e9c31000000
6.5 Inactivating the Function of Specific Genes in Eukaryotes lodish8e_ch6_34.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_34_dlap.xml572b8933757a2e9c31000000
Normal Yeast Genes Can Be Replaced with Mutant Alleles by Homologous Recombination lodish8e_ch6_35.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_35_dlap.xml572b8933757a2e9c31000000
Genes Can Be Placed Under the Control of an Experimentally Regulated Promoter lodish8e_ch6_36.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_36_dlap.xml572b8933757a2e9c31000000
Specific Genes Can Be Permanently Inactivated in the Germ Line of Mice lodish8e_ch6_37.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_37_dlap.xml572b8933757a2e9c31000000
Somatic Cell Recombination Can Inactivate Genes in Specific Tissues lodish8e_ch6_38.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_38_dlap.xml572b8933757a2e9c31000000
Dominant-Negative Alleles Can Inhibit the Function of Some Genes lodish8e_ch6_39.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_39_dlap.xml572b8933757a2e9c31000000
RNA Interference Causes Gene Inactivation by Destroying the Corresponding mRNA lodish8e_ch6_40.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_40_dlap.xml572b8933757a2e9c31000000
Engineered CRISPR–Cas9 Systems Allow Precise Genome Editing lodish8e_ch6_41.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_41_dlap.xml572b8933757a2e9c31000000
Key Concepts of Section 6.5lodish8e_ch6_42.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_42_dlap.xml572b8933757a2e9c31000000
Key Terms lodish8e_ch6_43.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_43_dlap.xml572b8933757a2e9c31000000
Review the Concepts lodish8e_ch6_44.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_44_dlap.xml572b8933757a2e9c31000000
Extended References lodish8e_ch6_45.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_45_dlap.xml572b8933757a2e9c31000000
Perspectives for the Future lodish8e_ch6_46.html572b8933757a2e9c31000000
DLAP questionslodish8e_ch6_46_dlap.xml572b8933757a2e9c31000000