FileTitleManuscript Id
Chapter Introductionlodish8e_ch15_1.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_1_dlap.xml572b8c37757a2eeb31000000
15.1 Signal Transduction: From Extracellular Signal to Cellular Response lodish8e_ch15_2.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_2_dlap.xml572b8c37757a2eeb31000000
Signaling Molecules Can Act Locally or at a Distance lodish8e_ch15_3.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_3_dlap.xml572b8c37757a2eeb31000000
Receptors Bind Only a Single Type of Hormone or a Group of Closely Related Hormones lodish8e_ch15_4.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_4_dlap.xml572b8c37757a2eeb31000000
Protein Kinases and Phosphatases Are Employed in Many Signaling Pathways lodish8e_ch15_5.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_5_dlap.xml572b8c37757a2eeb31000000
GTP-Binding Proteins Are Frequently Used in Signal Transduction Pathways as On/Off Switches lodish8e_ch15_6.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_6_dlap.xml572b8c37757a2eeb31000000
Intracellular “Second Messengers” Transmit Signals from Many Receptors lodish8e_ch15_7.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_7_dlap.xml572b8c37757a2eeb31000000
Signal Transduction Pathways Can Amplify the Effects of Extracellular Signals lodish8e_ch15_8.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_8_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.1lodish8e_ch15_9.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_9_dlap.xml572b8c37757a2eeb31000000
15.2 Studying Cell-Surface Receptors and Signal Transduction Proteins lodish8e_ch15_10.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_10_dlap.xml572b8c37757a2eeb31000000
The Dissociation Constant Is a Measure of the Affinity of a Receptor for Its Ligand lodish8e_ch15_11.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_11_dlap.xml572b8c37757a2eeb31000000
Binding Assays Are Used to Detect Receptors and Determine Their Affinity and Specificity for Ligands lodish8e_ch15_12.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_12_dlap.xml572b8c37757a2eeb31000000
Near-Maximal Cellular Response to a Signaling Molecule Usually Does Not Require Activation of All Receptors lodish8e_ch15_13.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_13_dlap.xml572b8c37757a2eeb31000000
Sensitivity of a Cell to External Signals Is Determined by the Number of Cell-Surface Receptors and Their Affinity for Ligand lodish8e_ch15_14.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_14_dlap.xml572b8c37757a2eeb31000000
Hormone Analogs Are Widely Used as Drugs lodish8e_ch15_15.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_15_dlap.xml572b8c37757a2eeb31000000
Receptors Can Be Purified by Affinity Chromatography Techniques lodish8e_ch15_16.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_16_dlap.xml572b8c37757a2eeb31000000
Immunoprecipitation Assays and Affinity Techniques Can Be Used to Study the Activity of Signal Transduction Proteins lodish8e_ch15_17.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_17_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.2lodish8e_ch15_18.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_18_dlap.xml572b8c37757a2eeb31000000
15.3 G Protein–Coupled Receptors: Structure and Mechanism lodish8e_ch15_19.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_19_dlap.xml572b8c37757a2eeb31000000
All G Protein–Coupled Receptors Share the Same Basic Structure lodish8e_ch15_20.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_20_dlap.xml572b8c37757a2eeb31000000
Ligand-Activated G Protein–Coupled Receptors Catalyze Exchange of GTP for GDP on the α Subunit of a Heterotrimeric G Protein lodish8e_ch15_21.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_21_dlap.xml572b8c37757a2eeb31000000
Different G Proteins Are Activated by Different GPCRs and In Turn Regulate Different Effector Proteins lodish8e_ch15_22.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_22_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.3lodish8e_ch15_23.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_23_dlap.xml572b8c37757a2eeb31000000
15.4 G Protein–Coupled Receptors That Regulate Ion Channels lodish8e_ch15_24.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_24_dlap.xml572b8c37757a2eeb31000000
Acetylcholine Receptors in the Heart Muscle Activate a G Protein That Opens K+ Channels lodish8e_ch15_25.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_25_dlap.xml572b8c37757a2eeb31000000
Light Activates Rhodopsin in Rod Cells of the Eye lodish8e_ch15_26.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_26_dlap.xml572b8c37757a2eeb31000000
Activation of Rhodopsin by Light Leads to Closing of cGMP-Gated Cation Channels lodish8e_ch15_27.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_27_dlap.xml572b8c37757a2eeb31000000
Signal Amplification Makes the Rhodopsin Signal Transduction Pathway Exquisitely Sensitive lodish8e_ch15_28.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_28_dlap.xml572b8c37757a2eeb31000000
Rapid Termination of the Rhodopsin Signal Transduction Pathway Is Essential for the Temporal Resolution of Vision lodish8e_ch15_29.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_29_dlap.xml572b8c37757a2eeb31000000
Rod Cells Adapt to Varying Levels of Ambient Light by Intracellular Trafficking of Arrestin and Transducin lodish8e_ch15_30.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_30_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.4lodish8e_ch15_31.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_31_dlap.xml572b8c37757a2eeb31000000
15.5 G Protein–Coupled Receptors That Activate or Inhibit Adenylyl Cyclase lodish8e_ch15_32.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_32_dlap.xml572b8c37757a2eeb31000000
Adenylyl Cyclase Is Stimulated and Inhibited by Different Receptor-Ligand Complexes lodish8e_ch15_33.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_33_dlap.xml572b8c37757a2eeb31000000
Structural Studies Established How Gαs·GTP Binds to and Activates Adenylyl Cyclase lodish8e_ch15_34.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_34_dlap.xml572b8c37757a2eeb31000000
cAMP Activates Protein Kinase A by Releasing Inhibitory Subunits lodish8e_ch15_35.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_35_dlap.xml572b8c37757a2eeb31000000
Glycogen Metabolism Is Regulated by Hormone-Induced Activation of PKA lodish8e_ch15_36.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_36_dlap.xml572b8c37757a2eeb31000000
cAMP-Mediated Activation of PKA Produces Diverse Responses in Different Cell Types lodish8e_ch15_37.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_37_dlap.xml572b8c37757a2eeb31000000
Signal Amplification Occurs in the cAMP-PKA Pathway lodish8e_ch15_38.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_38_dlap.xml572b8c37757a2eeb31000000
CREB Links cAMP and PKA to Activation of Gene Transcription lodish8e_ch15_39.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_39_dlap.xml572b8c37757a2eeb31000000
Anchoring Proteins Localize Effects of cAMP to Specific Regions of the Cell lodish8e_ch15_40.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_40_dlap.xml572b8c37757a2eeb31000000
Multiple Mechanisms Suppress Signaling from the GPCR/cAMP/PKA Pathway lodish8e_ch15_41.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_41_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.5lodish8e_ch15_42.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_42_dlap.xml572b8c37757a2eeb31000000
15.6 G Protein–Coupled Receptors That Trigger Elevations in Cytosolic and Mitochondrial Calcium lodish8e_ch15_43.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_43_dlap.xml572b8c37757a2eeb31000000
Calcium Concentrations in the Mitochondrial Matrix, ER, and Cytosol Can Be Measured with Targeted Fluorescent Proteins lodish8e_ch15_44.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_44_dlap.xml572b8c37757a2eeb31000000
Activated Phospholipase C Generates Two Key Second Messengers Derived from the Membrane Lipid Phosphatidylinositol 4,5-Bisphosphate lodish8e_ch15_45.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_45_dlap.xml572b8c37757a2eeb31000000
The Ca2+-Calmodulin Complex Mediates Many Cellular Responses to External Signals lodish8e_ch15_46.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_46_dlap.xml572b8c37757a2eeb31000000
DAG Activates Protein Kinase C lodish8e_ch15_47.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_47_dlap.xml572b8c37757a2eeb31000000
Integration of Ca2+ and cAMP Second Messengers Regulates Glycogenolysis lodish8e_ch15_48.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_48_dlap.xml572b8c37757a2eeb31000000
Signal-Induced Relaxation of Vascular Smooth Muscle Is Mediated by a Ca2+-Nitric Oxide-cGMP-Activated Protein Kinase G Pathway lodish8e_ch15_49.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_49_dlap.xml572b8c37757a2eeb31000000
Key Concepts of Section 15.6lodish8e_ch15_50.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_50_dlap.xml572b8c37757a2eeb31000000
Key Terms lodish8e_ch15_51.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_51_dlap.xml572b8c37757a2eeb31000000
Review the Concepts lodish8e_ch15_52.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_52_dlap.xml572b8c37757a2eeb31000000
References lodish8e_ch15_53.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_53_dlap.xml572b8c37757a2eeb31000000
Perspectives for the Future lodish8e_ch15_54.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_54_dlap.xml572b8c37757a2eeb31000000
Classic Experiment 15-1: The Infancy of Signal Transduction Studies: GTP Stimulation of cAMP Synthesislodish8e_ch15_55.html572b8c37757a2eeb31000000
DLAP questionslodish8e_ch15_55_dlap.xml572b8c37757a2eeb31000000