FileTitleManuscript Id
Chapter Introductionlodish8e_ch16_1.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_1_dlap.xml572b8d22757a2e1932000000
16.1 Receptor Serine Kinases That Activate Smads lodish8e_ch16_2.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_2_dlap.xml572b8d22757a2e1932000000
TGF-β Proteins Are Stored in an Inactive Form in the Extracellular Matrix lodish8e_ch16_3.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_3_dlap.xml572b8d22757a2e1932000000
Three Separate TGF-β Receptor Proteins Participate in Binding TGF-β and Activating Signal Transduction lodish8e_ch16_4.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_4_dlap.xml572b8d22757a2e1932000000
Activated TGF-β Receptors Phosphorylate Smad Transcription Factors lodish8e_ch16_5.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_5_dlap.xml572b8d22757a2e1932000000
The Smad3/Smad4 Complex Activates Expression of Different Genes in Different Cell Types lodish8e_ch16_6.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_6_dlap.xml572b8d22757a2e1932000000
Negative Feedback Loops Regulate TGF-β/Smad Signaling lodish8e_ch16_7.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_7_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.1lodish8e_ch16_8.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_8_dlap.xml572b8d22757a2e1932000000
16.2 Cytokine Receptors and the JAK/STAT Signaling Pathway lodish8e_ch16_9.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_9_dlap.xml572b8d22757a2e1932000000
Cytokines Influence the Development of Many Cell Types lodish8e_ch16_10.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_10_dlap.xml572b8d22757a2e1932000000
Binding of a Cytokine to Its Receptor Activates One or More Tightly Bound JAK Protein Tyrosine Kinases lodish8e_ch16_11.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_11_dlap.xml572b8d22757a2e1932000000
Phosphotyrosine Residues Are Binding Surfaces for Multiple Proteins with Conserved Domains lodish8e_ch16_12.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_12_dlap.xml572b8d22757a2e1932000000
SH2 Domains in Action: JAK Kinases Activate STAT Transcription Factors lodish8e_ch16_13.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_13_dlap.xml572b8d22757a2e1932000000
Multiple Mechanisms Down-Regulate Signaling from Cytokine Receptors lodish8e_ch16_14.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_14_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.2lodish8e_ch16_15.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_15_dlap.xml572b8d22757a2e1932000000
16.3 Receptor Tyrosine Kinases lodish8e_ch16_16.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_16_dlap.xml572b8d22757a2e1932000000
Binding of Ligand Promotes Dimerization of an RTK and Leads to Activation of Its Intrinsic Tyrosine Kinase lodish8e_ch16_17.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_17_dlap.xml572b8d22757a2e1932000000
Homo- and Hetero-oligomers of Epidermal Growth Factor Receptors Bind Members of the Epidermal Growth Factor Family lodish8e_ch16_18.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_18_dlap.xml572b8d22757a2e1932000000
Activation of the EGF Receptor Results in the Formation of an Asymmetric Active Kinase Dimer lodish8e_ch16_19.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_19_dlap.xml572b8d22757a2e1932000000
Multiple Mechanisms Down-Regulate Signaling from RTKs lodish8e_ch16_20.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_20_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.3lodish8e_ch16_21.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_21_dlap.xml572b8d22757a2e1932000000
16.4 The Ras/MAP Kinase Pathway lodish8e_ch16_22.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_22_dlap.xml572b8d22757a2e1932000000
Ras, a GTPase Switch Protein, Operates Downstream of Most RTKs and Cytokine Receptors lodish8e_ch16_23.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_23_dlap.xml572b8d22757a2e1932000000
Genetic Studies in Drosophila Identified Key Signal-Transducing Proteins in the Ras/MAP Kinase Pathway lodish8e_ch16_24.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_24_dlap.xml572b8d22757a2e1932000000
Receptor Tyrosine Kinases Are Linked to Ras by Adapter Proteins lodish8e_ch16_25.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_25_dlap.xml572b8d22757a2e1932000000
Binding of Sos to Inactive Ras Causes a Conformational Change That Triggers an Exchange of GTP for GDP lodish8e_ch16_26.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_26_dlap.xml572b8d22757a2e1932000000
Signals Pass from Activated Ras to a Cascade of Protein Kinases Ending with MAP Kinase lodish8e_ch16_27.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_27_dlap.xml572b8d22757a2e1932000000
Phosphorylation of MAP Kinase Results in a Conformational Change That Enhances Its Catalytic Activity and Promotes Its Dimerization lodish8e_ch16_28.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_28_dlap.xml572b8d22757a2e1932000000
MAP Kinase Regulates the Activity of Many Transcription Factors Controlling Early Response Genes lodish8e_ch16_29.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_29_dlap.xml572b8d22757a2e1932000000
G Protein–Coupled Receptors Transmit Signals to MAP Kinase in Yeast Mating Pathways lodish8e_ch16_30.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_30_dlap.xml572b8d22757a2e1932000000
Scaffold Proteins Separate Multiple MAP Kinase Pathways in Eukaryotic Cells lodish8e_ch16_31.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_31_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.4lodish8e_ch16_32.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_32_dlap.xml572b8d22757a2e1932000000
16.5 Phosphoinositide Signaling Pathways lodish8e_ch16_33.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_33_dlap.xml572b8d22757a2e1932000000
Phospholipase Cγ Is Activated by Some RTKs and Cytokine Receptors lodish8e_ch16_34.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_34_dlap.xml572b8d22757a2e1932000000
Recruitment of PI-3 Kinase to Activated Receptors Leads to Synthesis of Three Phosphorylated Phosphatidylinositols lodish8e_ch16_35.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_35_dlap.xml572b8d22757a2e1932000000
Accumulation of PI 3-Phosphates in the Plasma Membrane Leads to Activation of Several Kinases lodish8e_ch16_36.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_36_dlap.xml572b8d22757a2e1932000000
Activated Protein Kinase B Induces Many Cellular Responses lodish8e_ch16_37.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_37_dlap.xml572b8d22757a2e1932000000
The PI-3 Kinase Pathway Is Negatively Regulated by PTEN Phosphatase lodish8e_ch16_38.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_38_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.5lodish8e_ch16_39.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_39_dlap.xml572b8d22757a2e1932000000
16.6 Signaling Pathways Controlled by Ubiquitinylation and Protein Degradation: Wnt, Hedgehog, and NF-κB lodish8e_ch16_40.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_40_dlap.xml572b8d22757a2e1932000000
Wnt Signaling Triggers Release of a Transcription Factor from a Cytosolic Protein Complex lodish8e_ch16_41.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_41_dlap.xml572b8d22757a2e1932000000
Concentration Gradients of Wnt Protein Are Essential for Many Steps in Development lodish8e_ch16_42.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_42_dlap.xml572b8d22757a2e1932000000
Hedgehog Signaling Relieves Repression of Target Genes lodish8e_ch16_43.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_43_dlap.xml572b8d22757a2e1932000000
Hedgehog Signaling in Vertebrates Requires Primary Cilia lodish8e_ch16_44.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_44_dlap.xml572b8d22757a2e1932000000
Degradation of an Inhibitor Protein Activates the NF-κB Transcription Factor lodish8e_ch16_45.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_45_dlap.xml572b8d22757a2e1932000000
Polyubiquitin Chains Serve as Scaffolds Linking Receptors to Downstream Proteins in the NF-κB Pathway lodish8e_ch16_46.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_46_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.6lodish8e_ch16_47.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_47_dlap.xml572b8d22757a2e1932000000
16.7 Signaling Pathways Controlled by Protein Cleavage: Notch/Delta, SREBP, and Alzheimer’s Disease lodish8e_ch16_48.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_48_dlap.xml572b8d22757a2e1932000000
On Binding Delta, the Notch Receptor Is Cleaved, Releasing a Component Transcription Factor lodish8e_ch16_49.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_49_dlap.xml572b8d22757a2e1932000000
Matrix Metalloproteases Catalyze Cleavage of Many Signaling Proteins from the Cell Surface lodish8e_ch16_50.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_50_dlap.xml572b8d22757a2e1932000000
Inappropriate Cleavage of Amyloid Precursor Protein Can Lead to Alzheimer’s Disease lodish8e_ch16_51.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_51_dlap.xml572b8d22757a2e1932000000
Regulated Intramembrane Proteolysis of SREBPs Releases a Transcription Factor That Acts to Maintain Phospholipid and Cholesterol Levels lodish8e_ch16_52.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_52_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.7lodish8e_ch16_53.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_53_dlap.xml572b8d22757a2e1932000000
16.8 Integration of Cellular Responses to Multiple Signaling Pathways: Insulin Action lodish8e_ch16_54.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_54_dlap.xml572b8d22757a2e1932000000
Insulin and Glucagon Work Together to Maintain a Stable Blood Glucose Level lodish8e_ch16_55.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_55_dlap.xml572b8d22757a2e1932000000
A Rise in Blood Glucose Triggers Insulin Secretion from the β Islet Cells lodish8e_ch16_56.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_56_dlap.xml572b8d22757a2e1932000000
In Fat and Muscle Cells, Insulin Triggers Fusion of Intracellular Vesicles Containing the GLUT4 Glucose Transporter to the Plasma Membrane lodish8e_ch16_57.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_57_dlap.xml572b8d22757a2e1932000000
Insulin Inhibits Glucose Synthesis and Enhances Storage of Glucose as Glycogen lodish8e_ch16_58.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_58_dlap.xml572b8d22757a2e1932000000
Multiple Signal Transduction Pathways Interact to Regulate Adipocyte Differentiation Through PPARγ, the Master Transcriptional Regulator lodish8e_ch16_59.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_59_dlap.xml572b8d22757a2e1932000000
Inflammatory Hormones Cause Derangement of Adipose Cell Function in Obesity lodish8e_ch16_60.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_60_dlap.xml572b8d22757a2e1932000000
Key Concepts of Section 16.8lodish8e_ch16_61.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_61_dlap.xml572b8d22757a2e1932000000
Key Terms lodish8e_ch16_62.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_62_dlap.xml572b8d22757a2e1932000000
Review the Concepts lodish8e_ch16_63.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_63_dlap.xml572b8d22757a2e1932000000
References lodish8e_ch16_64.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_64_dlap.xml572b8d22757a2e1932000000
Perspectives for the Future lodish8e_ch16_65.html572b8d22757a2e1932000000
DLAP questionslodish8e_ch16_65_dlap.xml572b8d22757a2e1932000000